Basic Information
| LncRNA/CircRNA Name | LINC00312 |
| Synonyms | LINC00312, ERR-10, ERR10, LMCD1DN, LOH3CR2A, NAG-7, NAG7, NCRNA00312 |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_024065 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, ChIP, Cell proliferation assay etc. |
| Sample | blood, NSCLC tissues, cell lines (A549, SPC-A1, H1299, H1975, PC9 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Here, we found linc00312 was down-regulated in paired NSCLC tissues and correlated with poor clinical outcome; decreased linc00312 expression in NSCLC was associated with larger and later stage tumours. linc00312 could inhibit cell proliferation and promote apoptosis in vitro and in vivo. Furthermore, we found that HOXA5 could bind in the promoter of linc00312 and up-regulated the expression of it. Moreover, linc00312 was down-regulated in the plasma of NSCLC patients. |
| Pubmed ID | 28338293 |
| Year | 2017 |
| Title | Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer. |
External Links
| Links for LINC00312 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |