Basic Information
| LncRNA/CircRNA Name | LINC00312 |
| Synonyms | LINC00312, ERR-10, ERR10, LMCD1DN, LOH3CR2A, NAG-7, NAG7, NCRNA00312 |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_024065 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Flow cytometry, etc. |
| Sample | ovarian cancer tissues, cell lines (SKOV3, SKOV3/DDP) |
| Expression Pattern | down-regulated |
| Function Description | Linc00312 enhanced the sensitivity of SKOV3/DDP cells to cisplatin by promoting cell apoptosis via the Bcl-2/Caspase-3 signaling pathway. |
| Pubmed ID | 29952351 |
| Year | 2018 |
| Title | Long non-coding RNA Linc00312 modulates the sensitivity of ovarian cancer to cisplatin via the Bcl-2/Caspase-3 signaling pathway. |
External Links
| Links for LINC00312 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |