Basic Information
| LncRNA/CircRNA Name | LINC003121 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | cell lines (K1 (papillary TC), SW579(squamous TC), and 8505C(anaplastic TC)). TC tissues and adjacent normal tissues. |
| Expression Pattern | up-regulated |
| Function Description | LINC00312 can act as a tumor-suppressor in TC by attenuating the PI3K/Akt signaling pathway, and LINC00312 could be a novel diagnosis biomarker and a promising therapeutic target for TC patients. |
| Pubmed ID | 29969438 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC003121 Inhibits Proliferation and Invasion of Thyroid Cancer Cells by Suppression of the Phosphatidylinositol-3-Kinase (PI3K)/Akt Signaling Pathway. |
External Links
| Links for LINC003121 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |