Basic Information
| LncRNA/CircRNA Name | LINC00313 |
| Synonyms | C21orf84, NCRNA00313, CH507-42P11.5 |
| Region | GRCh38_21:43462094-43479534 |
| Ensemble | ENSG00000185186 |
| Refseq | NR_026863 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, Microarray, other |
| Sample | GBM tissues and cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of UPF1 or Linc-00313 significantly inhibited malignant biological behaviors of glioma cells by regulating miR-342-3p and miR-485-5p, which are downregulated and functioned as tumor suppressors in glioma. Furthermore, Linc-00313 could acted as a competing endogenous RNA(ceRNA) to regulate the expression of Zic4 by binding to miR-342-3p and miR-485-5p. Interestingly, Zic4 could bind to the promoters of UPF1 and Linc-00313 respectively and upregulate the expression of them. These results indicated that a positive-feedback loop was formed in the regulation of the biological behaviors of glioma cells. The study is the first to prove that the UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway forms a positive-feedback loop and regulates the biological behaviors of U87 and U251 cells, which might provide a new therapeutic target for glioma. |
| Pubmed ID | 31427569 |
| Year | 2019 |
| Title | UPF1 Regulates the Malignant Biological Behaviors of Glioblastoma Cells via Enhancing the Stability of Linc-00313 |
External Links
| Links for LINC00313 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |