Basic Information
| LncRNA/CircRNA Name | LINC00319 |
| Synonyms | NA |
| Region | GRCh38_21:43446601-43453893 |
| Ensemble | ENSG00000188660 |
| Refseq | NR_026960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | BCa tissues and their matched normal tissues ,BCa cell lines and normal bladder cell line (SV-HUC-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00319 was shown to be an upregulated lncRNA in BCa tissues. LINC00319 expression is negatively correlated with the patient's prognosis. Silencing of LINC00319 suppressed BCa proliferation and invasiveness.LINC00319 was a sponge for miR-4492 and miR-4492 suppressed ROMO1 expression in BCa.Furthermore, miR-4492/ROMO1 axis regulates proliferation, migration, and invasion and LINC00319 exerts oncogenic roles through modulating miR-4492/ROMO1 axis. |
| Pubmed ID | 31608995 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC00319 Regulates ROMO1 Expression and Promotes Bladder Cancer Progression via miR-4492/ROMO1 Axis |
External Links
| Links for LINC00319 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |