Basic Information
| LncRNA/CircRNA Name | LINC00319 |
| Synonyms | NA |
| Region | GRCh38_21:43446601-43453893 |
| Ensemble | ENSG00000188660 |
| Refseq | NR_026960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot, other |
| Sample | ovarian cancer tissues and cell lines (SKOV-3, CAOV3 and HO8910) |
| Expression Pattern | up-regulated |
| Function Description | LINC00319 upregulation promoted proliferation, migration and invasion of ovarian cancer cells. LINC00319 upregulates NACC1 expression through inhibiting miR-423-5p in ovarian cancer cells.NACC1 restoration rescued the potentials of proliferation, migration and invasion in LINC00319-depleted ovarian cancer cells. LINC00319 promotes ovarian cancer progression through upregulating NACC1 expression by restraining miR-423-5p. |
| Pubmed ID | 30442370 |
| Year | 2018 |
| Title | LncRNA LINC00319 accelerates ovarian cancer progression through miR-423-5p/NACC1 pathway. |
External Links
| Links for LINC00319 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |