Basic Information
| LncRNA/CircRNA Name | LINC00319 |
| Synonyms | NA |
| Region | GRCh38_21:43446601-43453893 |
| Ensemble | ENSG00000188660 |
| Refseq | NR_026960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | lung adenocarcinoma tissues, cell lines (H157, 95D, SPC-A-1, A549, SK-LU-1, Calu-3, HCC-78, H1299 and H1975) |
| Expression Pattern | up-regulated |
| Function Description | We observed that increased expression of LINC00319 in lung adenocarcinoma tissues and cells in comparison to their corresponding controls.Moreover,the aberrant overexpression of LINC00319 indicated the poor prognosis of lung adenocarcinoma patients.Silence of LINC00319 was able to repress lung adenocarcinoma cell growth in vitro.Rescue assay was performed to further confirm that LINC00319 contributed to lung adenocarcinoma progression by regulating miR-450b-5p/EZH2 signal pathway.Taken together, our study discovered the oncogenic role of LINC00319 in clinical specimens and cellular experiments,showing the potential LINC00319/miR-450b-5p/EZH2 pathway. |
| Pubmed ID | 29408583 |
| Year | 2018 |
| Title | Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2. |
External Links
| Links for LINC00319 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |