Basic Information
| LncRNA/CircRNA Name | LINC00339 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000218510 |
| Refseq | NR_023918 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | non small cell lung cancer tissues, cell lines (SK-MES-1, Calu-3, A549, H460, NHBE and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | LINC00339 was significantly up-regulated in NSCLC tissue and cells, which indicated the poor prognosis of NSCLC patients. The LINC00339 level was remarkably correlated with Tumor size, TNM stage , lymphonode metastasis in NSCLC. Loss-of-function experiments showed that LINC00339 silencing inhibited the proliferation and invasion, accelerated the apoptosis, and suppressed the tumor growth of NSCLC cells in vitro and in vivo. Luciferase reporter assay and RNA immunoprecipitation (RIP) revealed that LINC00339 promoted the NSCLC progression via FOXM1 via targeting miR-145. |
| Pubmed ID | 29906749 |
| Year | 2018 |
| Title | Long Non-Coding RNA LINC00339 Facilitates the Tumorigenesis of Non-Small Cell Lung Cancer by Sponging miR-145 Through Targeting FOXM1 |
External Links
| Links for LINC00339 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |