Basic Information
| LncRNA/CircRNA Name | LINC00346 |
| Synonyms | NA |
| Region | GRCh38_13:110863987-110870251 |
| Ensemble | ENSG00000255874 |
| Refseq | NR_027701 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot |
| Sample | tissues,cell lines (PANC-1, MIA PaCa-2, Capan-1, and BxPC-3) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of LINC00346 significantly enhanced the proliferation, colony formation, and tumorigenesis of pancreatic cancer cells. |
| Pubmed ID | 30728036 |
| Year | 2019 |
| Title | Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression. |
External Links
| Links for LINC00346 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |