Basic Information
| LncRNA/CircRNA Name | LINC00355 |
| Synonyms | NA |
| Region | GRCh38_13:63986371-64076011 |
| Ensemble | ENSG00000227674 |
| Refseq | NR_145420 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | Microarray, Dual Luciferase Reporter Gene Assay, qRT-PCR, Western blot analysis |
| Sample | HNSCC cell line UM-SCC 2 |
| Expression Pattern | up-regulated |
| Function Description | LINC00355 and HOXA10 were highly expressed in HNSCC, while miR-195 was poorly expressed.Silencing LINC00355 in these cells led to increased miR-195 expression and a reduction in HOXA10 expression, which inhibited viability, invasion, migration, and EMT and promoted apoptosis of CSCs. Silencing LINC00355 in vivo also led to decreased tumor growth. |
| Pubmed ID | 31837606 |
| Year | 2020 |
| Title | LINC00355 Promotes Tumor Progression in HNSCC by Hindering MicroRNA-195-Mediated Suppression of HOXA10 Expression |
External Links
| Links for LINC00355 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |