Basic Information
| LncRNA/CircRNA Name | LINC00365 |
| Synonyms | NA |
| Region | GRCh38_13:30103178-30108875 |
| Ensemble | ENSG00000224511 |
| Refseq | NR_046998 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00365 overexpression significantly inhibited gastric cancer cell viability through the impairment of proliferation rather than the promotion of apoptosis. Furthermore, overexpressed LINC00365 upregulated SCGB2A1 in gastric cancer cell lines. Immuno-fluorescence and luciferase assay analysis indicated that LINC00365 overexpression inhibited the NF-?B prosurvival signaling pathway. |
| Pubmed ID | 32095083 |
| Year | 2020 |
| Title | The LINC00365/SCGB2A1 (Mammaglobin B) Axis Down-Regulates NF-?B Signaling and Is Associated with the Progression of Gastric Cancer |
External Links
| Links for LINC00365 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |