Basic Information
| LncRNA/CircRNA Name | LINC00449 |
| Synonyms | NA |
| Region | GRCh38_13:99499727-99501052 |
| Ensemble | ENSG00000203441 |
| Refseq | NR_133664 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Luciferase reporter assay, RIP, Western blotting assay |
| Sample | the mononuclear cells derived from peripheral blood or BM,cell lines (THP-1 and U937) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA LINC00449 was significantly downregulated in AML samples.LINC00449 restrained cell proliferation and migration in AML cells. LINC00449 predicts a favorable prognosis of patients with AML. LINC00449 regulated FOXD3 by targeting and miR-150. |
| Pubmed ID | 31960456 |
| Year | 2020 |
| Title | LINC00449 regulates the proliferation and invasion of acute monocytic leukemia and predicts favorable prognosis |
External Links
| Links for LINC00449 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |