Basic Information
| LncRNA/CircRNA Name | LINC00459 |
| Synonyms | NA |
| Region | GRCh38_13:62323657-62328833 |
| Ensemble | ENSG00000229307 |
| Refseq | NR_047038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blotting, Luciferase reporter assay, RIP |
| Sample | tissue samples,Melanoma cell lines (A375 and UACC903) and human melanocyte cells (HEM) |
| Expression Pattern | down-regulated |
| Function Description | The results demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the in-vitro and in-vivo experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. Bioinformatics analyses suggested that miR-218 could be a direct target of LINC00459. |
| Pubmed ID | 31844121 |
| Year | 2019 |
| Title | LINC00459 Sponging miR-218 to Elevate DKK3 Inhibits Proliferation and Invasion in Melanoma |
External Links
| Links for LINC00459 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |