Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot assay, Luciferase reporter assay |
| Sample | PTC tissues,thyroid epithelial cell line (Nthy-ori 3-1) and the PTC cell lines (FTC-133 and 8505C) |
| Expression Pattern | up-regulated |
| Function Description | LINC00460 was upregulated in PTC tissues and cells.High LINC00460 expression was associated with poor prognosis. LINC00460 knockdown suppressed proliferation, migration, invation and EMT of PTC cells.LINC00460 promoted PTC progression by sponging miR-485-5p to elevate the expression of Raf1. Knockdown of LINC00460 restrained tumor growth in vivo. |
| Pubmed ID | 31870440 |
| Year | 2019 |
| Title | LncRNA LINC00460 Promotes the Papillary Thyroid Cancer Progression by Regulating the LINC00460/miR-485-5p/Raf1 Axis |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |