Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, ChIP, RIP |
| Sample | colorectal cancer tissues, cell lines (HCT116, SW480, HT-29, Lovo) |
| Expression Pattern | up-regulated |
| Function Description | real-time qPCR results also verified that LINC00460 was overexpressed in CRC tissues and cells. high LINC00460 expression levels in CRC specimens were correlated with larger tumor size, advanced tumor stage, lymph node metastasis and shorter overall survival. In vitro and in vivo assays of LINC00460 alterations revealed a complex integrated phenotype affecting cell growth and apoptosis. LINC00460 also functioned as a molecular sponge for miR-149-5p, antagonizing its ability to repress cullin 4A (CUL4A) protein translation. |
| Pubmed ID | 30092404 |
| Year | 2018 |
| Title | A Novel lncRNA, LINC00460, Affects Cell Proliferation and Apoptosis by Regulating KLF2 and CUL4A Expression in Colorectal Cancer. |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |