Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, RNAi, Western blot, Cell migration and invasion assay, CCK-8 assay etc. |
| Sample | RCC tissues, cell lines (786-O, A498, caki-1 and caki-2, and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | ANRIL was highly expressed in RCC tissues and RCC cell lines. ANRIL significantly promoted cell proliferation, migration, invasion and EMT but inhibited cell apoptosis. Additionally, the expression levels of B-catenin, Ki-67, glycogen synthase kinase 3B (GSK-3B), phosphorylated GSK-3B, T cell transcription factor 4 (TCF-4) and leukemia enhancer factor 1 (LEF-1) were all markedly up-regulated by ANRIL. |
| Pubmed ID | 28251886 |
| Year | 2017 |
| Title | Highly Expressed Antisense Non-coding RNA in the INK4 Locus Promotes 5 Growth and Invasion of Renal Clear Carcinoma Cells Via the B-catenin Pathway. |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |