Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NR_034119 |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RNA-seq, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | tissues, NPC cell lines (SUNE-1, CNE-1, HNE-1, CNE-2, C666-1 and HONE-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00460 was markedly increased in NPC tissues and cells compared to their corresponding controls. Silencing LINC00460 was able to suppress NPC cell growth in vitro while overexpressing LINC00460 reversed this process. LINC00460 contributed to the progression of NPC through regulating miR-149-5p/IL6 signal pathway. |
| Pubmed ID | 28987345 |
| Year | 2017 |
| Title | LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6. |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |