Basic Information
| LncRNA/CircRNA Name | LINC00461 |
| Synonyms | NA |
| Region | GRCh38_5:88507546-88691041 |
| Ensemble | ENSG00000245526 |
| Refseq | NR_024384 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RIP, Luciferase reporter assay etc |
| Sample | breast cancer surgery resected tissue, cell line (MCF 10A (CBP60419),U565 (CBP60353), MCF-7 (CBP60380), MDA-MB-157 (CBP60381) and MDA-MB-231 (CBP60382)) |
| Expression Pattern | up-regulated |
| Function Description | LINC00461 was predicted to regulate KPNA2 through sponging miR-144-3p as revealed by the ceRNA network. Besides, LINC00461 and KPNA2 were found to be remarkably highly-expressed in breast cancer cells, while miR-144-3p was poorly-expressed. Silencing LINC00461 could promote miR-144-3p expression, thus inhibiting cell invasion and migration. |
| Pubmed ID | 32355466 |
| Year | 2020 |
| Title | A long non-coding RNA LINC00461-dependent mechanism underlying breast cancer invasion and migration via the miR-144-3p/KPNA2 axis. |
External Links
| Links for LINC00461 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |