Basic Information
| LncRNA/CircRNA Name | LINC00461 |
| Synonyms | NA |
| Region | GRCh38_5:88507546-88691041 |
| Ensemble | ENSG00000245526 |
| Refseq | NR_024384 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot |
| Sample | Tissue specimens,normal bronchial epithelial cell line 16HBE, human NSCLC cell lines A549, H1299,H23 and SPC-A1 |
| Expression Pattern | up-regulated |
| Function Description | LINC00461 was highly expressed in NSCLC tissues and cell lines.LINC00461 expression in advanced stage was much higher than in early stage. Loss-of-function experiments suggested that LINC00461 knockdown impaired cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT). |
| Pubmed ID | 31934717 |
| Year | 2020 |
| Title | LINC00461/miR-4478/E2F1 Feedback Loop Promotes Non-Small Cell Lung Cancer Cell Proliferation and Migration |
External Links
| Links for LINC00461 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |