Basic Information
| LncRNA/CircRNA Name | LINC00467 |
| Synonyms | long intergenic non-protein coding RNA 467 |
| Region | GRCh38_1:211382803-211435333 |
| Ensemble | ENSG00000153363 |
| Refseq | NR_026761 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot assay, RIP, Luciferase reporter assay |
| Sample | liver epithelial cell line (THLE-3) and the human HCC cell lines (HCCLM3,Hep3B, HepG2, Huh-7) |
| Expression Pattern | up-regulated |
| Function Description | LINC00467 upregulation in HCC tissues and cells was observed. LINC00467 silencing suppressed cell proliferation and metastasis, whereas it facilitated cell apoptosis in HCC.LINC00467 deficiency could decrease the mRNA stability of TRAF5 in HCC.LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in HCC. |
| Pubmed ID | 31656043 |
| Year | 2020 |
| Title | LINC00467 Promotes Cell Proliferation and Metastasis by Binding With IGF2BP3 to Enhance the mRNA Stability of TRAF5 in Hepatocellular Carcinoma |
External Links
| Links for LINC00467 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |