Basic Information
| LncRNA/CircRNA Name | LINC00467 |
| Synonyms | LINC00467, C1orf97 |
| Region | GRCh38_1:211382803-211435333 |
| Ensemble | ENSG00000153363 |
| Refseq | NR_026761 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Luciferase reporter assay etc. |
| Sample | cell lines (BE(2)-C) |
| Expression Pattern | differential expression |
| Function Description | Chromatin immunoprecipitation and luciferase assays showed that N-Myc suppressed linc00467 gene expression through direct binding to the linc00467 gene promoter and reducing linc00467 promoter activity. While N-Myc suppressed the expression of RD3, the protein-coding gene immediately down-stream of linc00467 gene, through direct binding to the RD3 gene promoter and reducing RD3 promoter activity, linc00467 reduced RD3 mRNA expression. Importantly, knocking-down linc00467 expression with siRNA in neuroblastoma cells reduced the number of viable cells and increased the percentage of apoptotic cells, and co-transfection with DKK1 siRNA blocked the effects. |
| Pubmed ID | 24586304 |
| Year | 2014 |
| Title | The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc. |
External Links
| Links for LINC00467 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |