Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | NA |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR etc. |
| Sample | human gastric carcinoma tissues and adjacent normal tissues ,cell lines(AGS, AZ-521, HR, TSGH, SNU- 1, and NCI-N87) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of Linc00472 significantly decreased in gastric cancer tissues compared to adjacent normal tissues. Furthermore, we observed a more frequent hypermethylation of CpG islands upstream of Linc00472 in gastric cancer tissues. Ectopic Linc00472 expression could significantly inhibit gastric cancer cell growth and migration. |
| Pubmed ID | 31570433 |
| Year | 2019 |
| Title | Aberrant DNA Hypermethylation Silenced LncRNA Expression in Gastric Cancer |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |