Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | NA |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | fresh HCC tissues, human liver cell line LO2 and HCC cell lines HepG2, BEL-7404, Hep3B, SMMC-7721, Huh-7 |
| Expression Pattern | down-regulated |
| Function Description | long non-coding RNA (lncRNA) LINC00472 was low expressed in human HCC tissues and cell lines compared with adjacent non-tumor liver tissues and normal liver cell lines respectively. LINC00472 was also low expressed in HCC tissues from patients with metastasis compared with tissues from patients without metastasis. Expression level of LINC00472 was positively correlated with patient overall survival (OS) rate. Forced expression of LINC00472 suppressed cell proliferation, migration, invasion and promoted cell apoptosis in HCC cells Huh-7 and SMMC-7721. MiR-93-5p was a direct target of LINC00472, and miR-93-5p directly targeted PDCD4. The miR-93-5p/PDCD4 pathway mediated the suppressing role of LINC00472 in HCC cells. |
| Pubmed ID | 30522853 |
| Year | 2018 |
| Title | Long non-coding RNA LINC00472 suppresses hepatocellular carcinoma cell proliferation, migration and invasion through miR-93-5p/PDCD4 pathway |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |