Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | NA |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | abdominal aortic aneurysm |
| ICD-0-3 | NA |
| Methods | RT-qPCR, RIP, Western blotting, Dual Luciferase reporter assay |
| Sample | AAA tissues,Human vascular smooth muscle cells (VSMCs) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of LINC00473 inhibited VSMC cell proliferation and promoted cell apoptosis and its silence mitigated H2O2-induced injuries to VSMCs. AAA development by regulating miR-212-5p/BASP1 pathway.LINC00473 sponged miR-212-5p to regulate brain acid soluble protein 1 (BASP1) expression. |
| Pubmed ID | 31954705 |
| Year | 2020 |
| Title | LINC00473 Inhibits Vascular Smooth Muscle Cell Viability to Promote Aneurysm Formation via miR-212-5p/BASP1 Axis |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for abdominal aortic aneurysm | OMIM COSMIC |