Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | NA |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissues, cell lines (AGS, RF-1, NCI-N87, KATO III, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00473 expression was increased in GC tissue samples and GC cell lines compared with paired adjacent normal stomach tissue samples and normal gastric epithelial cell line, respectively. High-expression of LINC00473 was correlated with poor histological type, advanced clinical stage, more lymph node metastasis and present distant metastasis.The results of western blot revealed down-regulation of LINC00473 obviously reduced MMP2, MMP9 and Vimentin protein expressions, and increased E-cadherin protein expression. |
| Pubmed ID | 30071345 |
| Year | 2018 |
| Title | LINC00473 Predicts Poor Prognosis and Regulates Cell Migration and Invasion in Gastric Cancer. |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |