Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | LINC00473, C6orf176, bA142J11.1 |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot, Microarray, other |
| Sample | HNSCC tissues and cell liness (SCC9, SCC15,SCC25, and CAL27) |
| Expression Pattern | up-regulated |
| Function Description | Functional assays showed that LINC00473 acted as oncogene to promote cell proliferation and inhibit apoptosis. In addition, downregulation of LINC00473 enhanced the sensitivity of radiotherapy for HNSCC cells. Furthermore, Western blot assays demonstrated that Wnt/?-catenin signaling pathway was inhibited by LINC00473 knockdown. Notably, Western blot assay revealed that x-ray treatment suppressed the activity of Wnt/?-catenin signaling pathway after LINC00473 knockdown. |
| Pubmed ID | 30468475 |
| Year | 2018 |
| Title | Upregulation of lncRNA LINC00473 Promotes Radioresistance of HNSCC Cells Through Activating Wnt/?-catenin Signaling Pathway |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |