Basic Information
| LncRNA/CircRNA Name | LINC00483 |
| Synonyms | C17orf73, FLJ20694 |
| Region | GRCh38_17:50761029-50767557 |
| Ensemble | ENSG00000167117 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | Cervical cancer tissues and cell lines HeLa, CaSki, C33A, ME180, SiHa |
| Expression Pattern | up-regulated |
| Function Description | Knock-down of Linc00483 inhibited cervical cancer cell proliferation, invasion as well as migration, and promoted cell apoptosis. In addition, miR-508-3p was identified as the downstream target of Linc00483, and miR-508-3p inhibitor abrogated the inhibiting effects of downregulated Linc00483 on cervical cancer cell viability. Furthermore, the expression levels of Linc00483 was positively correlated with RGS17 in the clinical samples and overexpressed Linc00483 increased RGS17 expression levels in cervical cancer cells by sponging miR-508-3p. The in vivo experiments showed that knock-down of Linc00483 inhibited cervical cancer cell tumorigenesis and lung metastasis in mice models. |
| Pubmed ID | 31454494 |
| Year | 2019 |
| Title | Long Non-Coding RNA Linc00483 Accelerated Tumorigenesis of Cervical Cancer by Regulating miR-508-3p/RGS17 Axis |
External Links
| Links for LINC00483 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |