Basic Information
| LncRNA/CircRNA Name | LINC00483 |
| Synonyms | C17orf73, FLJ20694 |
| Region | GRCh38_17:50761029-50767557 |
| Ensemble | ENSG00000167117 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | LAD tissues, cell line(H1299,A549, PC9, LTEP-A-2, NCI-H1650, human LAD cell lines, MRC-5 cell lines, and human embryonic lung fibroblasts) |
| Expression Pattern | up-regulated |
| Function Description | Also, the effect of LINC00483 on cell migration and invasion ability, and cell tumorigenic ability was detected. LINC00483 and HOXA10 were found to be upregulated whereas miR 144 was downregulated in LAD. Silencing of LINC00483 could competitively bind to miR 144, thereby upregulating HOXA10. LINC00483 or HOXA10 silencing led to decreased HOXA10, MMP 2, MMP 9, vimentin, and N cadherin but elevated miR 144 and E cadherin. Moreover, after being transfected with silenced LINC00483, the cell proliferation, migration, and invasion were inhibited with enhanced radiosensitivity. Consequently, the data of the study indicates that interference of LINC00483 weakens its competitive binding ability to miR 144, thus reducing HOXA10 expression, and enhancing radiosensitivity in LAD. |
| Pubmed ID | 30714135 |
| Year | 2019 |
| Title | Long noncoding RNA LINC00483/microRNA-144 regulates radiosensitivity and epithelial-mesenchymal transition in lung adenocarcinoma by interacting with HOXA10 |
External Links
| Links for LINC00483 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |