Basic Information
| LncRNA/CircRNA Name | LINC00488 |
| Synonyms | NA |
| Region | GRCh38_3:109178165-109185257 |
| Ensemble | ENSG00000214381 |
| Refseq | NR_026767 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP etc. |
| Sample | HCC tissues and paracancerous tissues ,human normal liver cell line L02 and human HCC cell lines (Huh-7, Hep3B, HCCLM3 and MHCC97) |
| Expression Pattern | up-regulated |
| Function Description | LINC00488 was notably expressed at a higher level in HCC tissues than in the paracancerous tissues.Cells with siRNA-mediated depletion of LINC00488 or restoration of miR-330-5p displayed suppressed abilities of in vitro proliferation as well as of in vivo tumor growth and angiogenesis, while in vitro apoptosis was notably induced. |
| Pubmed ID | 31005556 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC00488 Functions as a ceRNA to Regulate Hepatocellular Carcinoma Cell Growth and Angiogenesis Through miR-330-5 |
External Links
| Links for LINC00488 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |