Basic Information
| LncRNA/CircRNA Name | LINC00491 |
| Synonyms | NA |
| Region | GRCh38_5:102609156-102671559 |
| Ensemble | ENSG00000250682 |
| Refseq | NR_103753 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | colon adenocarcinoma tissues, colon adenocarcinoma cell lines (HT-29, HCT116) and normal colon epithelial cell line (NCM460) |
| Expression Pattern | up-regulated |
| Function Description | Bioinformatics analysis with the TCGA colon adenocarcinoma dataset showed that LINC00491 was significantly up-regulated in colon adenocarcinoma. Furthermore, we found that LINC00491 positively regulates SERPINE1 expression through sponging miR-145 and promoting the proliferation, migration, and invasion of colon adenocarcinoma cells, thus playing an oncogenic role during colon adenocarcinoma pathogenesis. Conclusion: LINC00491 functions as a ceRNA to promote SERPINE1 expression by sponging miR-145. LINC00491 serves as a therapeutic target and prognostic biomarker in colon adenocarcinoma |
| Pubmed ID | 31496744 |
| Year | 2019 |
| Title | LINC00491 as a new molecular marker can promote the proliferation, migration and invasion of colon adenocarcinoma cells |
External Links
| Links for LINC00491 | GenBank HGNC NONCODE |
| Links for colon adenocarcinoma | OMIM COSMIC |