Basic Information
| LncRNA/CircRNA Name | LINC00504 |
| Synonyms | NA |
| Region | GRCh38_4:14470465-14888169 |
| Ensemble | ENSG00000248360 |
| Refseq | NR_126435 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | OC tissues,HOSEpiC (the normal ovarian surface epithelial cell line) and five human OC cell lines A2780, CAOV-3, HO-8910, OVCAR-3 and SKOV-3 |
| Expression Pattern | up-regulated |
| Function Description | LINC00504 was upregulated in OC cell lines and specimens. Knockdown of LINC00504 inhibited cell proliferation, enhanced apoptosis, decreased glycolysis-related gene (PKM2, HK2, and PDK1) expression, and altered aerobic glycolysis in OC cells and vice versa. LINC00504 downregulated miR-1244 expression levels by acting as an endogenous sponge of miR-1244. |
| Pubmed ID | 31691157 |
| Year | 2020 |
| Title | Long Non-Coding RNA LINC00504 Regulates the Warburg Effect in Ovarian Cancer Through Inhibition of miR-1244 |
External Links
| Links for LINC00504 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |