Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | cell lines (MKN-45, BGC-823, HGC-27, and MGC-803) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 expression is upregulated in GC, promoting cell proliferation but suppressing cell apoptosisLINC00511 promotes gastric cancer cell growth by acting as a ceRNA to regulate the miR-124-3p/PDK4 axis, which may be a promising therapeutic target for GC. |
| Pubmed ID | 32368318 |
| Year | 2020 |
| Title | LINC00511 promotes gastric cancer cell growth by acting as a ceRNA. |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |