Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , RIP , in vitro knockdown etc. |
| Sample | ovarian cancer and normal tissues ,ovarian cancer cell line SKOV3 and SNU840 |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 expression was significantly up-regulated in ovarian cancer, and loss of function assays revealed its oncogenic role.Knockdown of LINC00511 inhibits ovarian cancer cells proliferation.LINC00511 represses P21 expression through interacting with EZH2.LINC00511 might be useful candidates for ovarian cancer patients outcome prediction. |
| Pubmed ID | 31016892 |
| Year | 2019 |
| Title | An Integrated Analysis Reveals the Oncogenic Function of lncRNA LINC00511 in Human Ovarian Cancer |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |