Basic Information
| LncRNA/CircRNA Name | ABHD11-AS1 |
| Synonyms | LINC00035, NCRNA00035, WBSCR26 |
| Region | NA |
| Ensemble | ENSG00000225969 |
| Refseq | NR_026690 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RIP, Luciferase reporter assay, Western blot, other |
| Sample | CRC tissues and cell lines (SW480, HT-29, LoVo, HCT-116, HCT-8, SW620, Caco-2) |
| Expression Pattern | up-regulated |
| Function Description | Silencing of ABHD11-AS1 expression could significantly reduce the proliferation, colony formation, migration and invasion of colorectal cancer cells, and increase cell apoptosis. Moreover, ABHD11-AS1 straightly interacted with miR-133a. Collectively, these findings manifested that the ABHD11-AS1/miR-133a/SOX4 axis may be a cogitable and promising therapeutic target for colorectal cancer. |
| Pubmed ID | 30429229 |
| Year | 2018 |
| Title | Long Non-Coding RNA ABHD11-AS1 Promotes Colorectal Cancer Development Through Regulation of miR-133a/SOX4 Axis |
External Links
| Links for ABHD11-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |