Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Normal human bronchial epithelial cell line (BEAS-2B) and lung cancer cell lines (A549, PC9 and H460), NSCLC and non-tumoral adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 is upregulated in NSCLC tissues and cell lines. It is closely related to tumor size, tumor stage, lymph node metastasis and, distant metastasis of NSCLC patients. Knockdown of LINC00511 attenuates proliferative, migratory and invasive capacities, but induces apoptosis of NSCLC cells. LATS2 and KLF2 are target genes of LINC00511, which are regulated by LINC00511 through binding to EZH2 and LSD1, thus influencing the progression of NSCLC. |
| Pubmed ID | 31646568 |
| Year | 2019 |
| Title | LINC00511 promotes the progression of non small cell lung cancer through downregulating LATS2 and KLF2 by binding to EZH2 and LSD1 |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |