Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | LINC00511, LCAL5, onco-lncRNA-12 |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | tongue squamous cell carcinoma tissues, cell lines (HOEC, Tca-8113, SCC-9, SCC-4 and CAL-2) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 was obviously upregulated in TSCC tissues and cell lines.Moreover,it was found that LINC00511 served as a competing endogenous RNA (ceRNA) through sponging miR-765 and ultimately modulated the derepression of laminin subunit gamma 2 (LAMC2).The inhibitory effects of miR-765 on TSCC cells proliferation,invasion as well as cell cycle distribution can be restored by the ectopic overexpression of LINC00511. Additionally, the restored capacity of LINC00511 promoted the expression of LAMC2, which was a downstream target of miR-765 and can be negatively regulated by miR-765. A novel molecular axis of LINC00511/miR-765/LAMC2 was investigated to regulate the tumor development of TSCC. LINC00511 promoted the expression of LAMC2 via the ceRNA mechanism of sponging miR-765. |
| Pubmed ID | 29315846 |
| Year | 2018 |
| Title | LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2. |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |