Basic Information
| LncRNA/CircRNA Name | LINC00518 |
| Synonyms | NA |
| Region | GRCh38_6:10429255-10434874 |
| Ensemble | ENSG00000183674 |
| Refseq | NR_027793 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | real-time PCR, Luciferase reporter assay, Western blot, other |
| Sample | human prostate epithelial cell line RWPE-1 and prostate tumor cell lines LNCap, DU145 and PC3 |
| Expression Pattern | up-regulated |
| Function Description | High level of Linc00518 transcripts associated with paclitaxel resistance. Linc00518 competitively inhibited miR-216b-5p through sponging mechanism. Linc00518 deficiency compromised the paclitaxel resistance in the acquired resistance cell lines. Overexpression of Linc00518 contributed to the paclitaxel resistance in prostate cancer via sequestering miR-216b-5p. |
| Pubmed ID | 30462844 |
| Year | 2019 |
| Title | Long Non-Coding RNA Linc00518 Promotes Paclitaxel Resistance of the Human Prostate Cancer by Sequestering miR-216b-5p |
External Links
| Links for LINC00518 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |