Basic Information
| LncRNA/CircRNA Name | LINC00565 |
| Synonyms | NA |
| Region | GRCh38_13:113926514-113928844 |
| Ensemble | ENSG00000260910 |
| Refseq | NR_047495 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown, RIP etc. |
| Sample | GC tissues and gastric mucosal tissues adjacent to GC tissues,human normal gastric epithelial cell line (GES-1) and GC cell lines (HGC, MGC, MKN28, MKN25, and AGS) |
| Expression Pattern | up-regulated |
| Function Description | Expression level of LINC00565 in GC tissue was highly expressed in GC, which was negatively correlated to prognosis of GC patients. Knockdown of LINC00565 decreased proliferative and colony formation abilities, and induced apoptosis of GC cells. LINC00565 was positively correlated with AKT3. Besides, AKT3 was significantly up-regulated in GC. In addition, knockdown of LINC00565 down-regulated AKT3. In order to explore the mechanism, we found that miR-665 could bind to LINC00565 by bioinformatics. Dual-luciferase reporter gene assay and RIP assay both verified the binding relationship between miR-665 and AKT3. |
| Pubmed ID | 31576144 |
| Year | 2019 |
| Title | LINC00565 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer by Targeting miR-665/AKT3 Axis |
External Links
| Links for LINC00565 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |