Basic Information
| LncRNA/CircRNA Name | LINC00612 |
| Synonyms | NA |
| Region | GRCh38_12:9055586-9065070 |
| Ensemble | ENSG00000214851 |
| Refseq | NR_034140 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi etc |
| Sample | osteosarcoma tissue, cell lines (hBMSCs, HFF-1,U2OS, Saos-2, MG63, HOS ) |
| Expression Pattern | down-regulated |
| Function Description | The in vitro functional effects of LINC00612 downregulation and overexpression on osteosarcoma cells were evaluated by CCK-8 assay, colony formation assay, scratch assay, transwell invasion assay and flow cytometry; in vivo tumor xenografts were conducted in nude mice. The effects of LINC00612 downregulation and overexpression on epithelial-mesenchymal transition (EMT) were assessed by scratch assay, transwell assay and qRT-PCR. The possibility of LINC00612 acting as a competing endogenous RNA (ceRNA) to target microRNA miR-214-5p was examined by dual-luciferase reporter assay. |
| Pubmed ID | 32311343 |
| Year | 2020 |
| Title | LINC00612 functions as a ceRNA for miR-214-5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo.functions as a ceRNA for miR-214-5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo. |
External Links
| Links for LINC00612 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |