Basic Information
| LncRNA/CircRNA Name | LINC00629 |
| Synonyms | NA |
| Region | GRCh38_X:134549973-134559923 |
| Ensemble | ENSG00000227060 |
| Refseq | NR_038998 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, Dual luciferase reporter gene assay, Western blot analysis, RIP, RT-qPCR |
| Sample | Tumor tissues,Gastric cancer cell lines (AGS, MKN45, BGC-823, and SCG7901) |
| Expression Pattern | down-regulated |
| Function Description | In gastric cancer, expression of LINC00629 and AQP4 was downregulated, and expression of miR-196b-5p was upregulated. Proliferation, invasion, and migration of gastric cancer cells were reduced after overexpression of LINC00629. LINC00629 competitively bound to miR-196b-5p, while AQP4 was a target of miR-196b-5p. Either downregulating miR-196b-5p or upregulating AQP4 could restrain the development of gastric cancer in vitro. LINC00629 overexpression repressed the growth of transplanted tumors in vivo. |
| Pubmed ID | 31674022 |
| Year | 2020 |
| Title | Long Noncoding RNA LINC00629 Restrains the Progression of Gastric Cancer by Upregulating AQP4 Through Competitively Binding to miR-196b-5p |
External Links
| Links for LINC00629 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |