Basic Information
| LncRNA/CircRNA Name | LINC00641 |
| Synonyms | NA |
| Region | GRCh38_14:21200079-21206900 |
| Ensemble | ENSG00000258441 |
| Refseq | NR_038970 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | NSCLC cell 54 lines A549, H1299, H1650 and H1975, Normal human bronchial epithelial cell line BEAS-2B |
| Expression Pattern | down-regulated |
| Function Description | downregulation of LINC00641 was identified in NSCLC cells. Functionally, LINC00641 suppressed cell proliferation and induced cell apoptosis in NSCLC, indicating that LINC00641 exerted tumor-suppressive role in NSCLC. Through mechanism investigation, we determined that LINC00641 acted as a competing endogenous RNA (ceRNA) in NSCLC by sponging miR-424-5p to upregulate phospholipid scramblase (PLSCR4) expression. Further rescue assays indicated that miR-424-5p and PLSCR4 could reverse LINC00641- mediated cellular processes. |
| Pubmed ID | 31322545 |
| Year | 2019 |
| Title | Long non-coding RNA LINC00641 suppresses non-small-cell lung cancer by sponging miR-424-5p to upregulate PLSCR4 |
External Links
| Links for LINC00641 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |