Basic Information
| LncRNA/CircRNA Name | LINC00651 |
| Synonyms | TRERNA1, LINC00651, treRNA |
| Region | GRCh38_20:50040716-50041504 |
| Ensemble | ENSG00000231265 |
| Refseq | NR_051976 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Lentiviral infection, Luciferase reporter assay, RNA pull-down assay, Cell proliferation assay etc. |
| Sample | cell line (MCF7) |
| Expression Pattern | up-regulated |
| Function Description | We found that treRNA is upregulated in paired clinical breast cancer primary and lymph-node metastasis samples, and that its expression stimulates tumour invasion in vitro and metastasis in vivo. Interestingly, we found that treRNA downregulates the expression of the epithelial marker E-cadherin by suppressing the translation of its mRNA. We identified a novel ribonucleoprotein (RNP) complex, consisting of RNA-binding proteins (hnRNP K, FXR1, and FXR2), PUF60 and SF3B3, that is required for this treRNA functions. Translational suppression by treRNA is dependent on the 3'UTR of the E-cadherin mRNA. Taken together, our study indicates a novel mechanism of gene regulation by lncRNAs in cancer progression. |
| Pubmed ID | 23974796 |
| Year | 2013 |
| Title | Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. |
External Links
| Links for LINC00651 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |