Basic Information
| LncRNA/CircRNA Name | LINC00662 |
| Synonyms | NA |
| Region | GRCh38_19:27684580-27793940 |
| Ensemble | ENSG00000261824 |
| Refseq | NR_027301 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | HCC tissues,cell lines(QSG-7701, HCC cells HCCLM3, MHCC97H, Huh7, and SK-HEP-1,THP-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00662 was found to be upregulated in HCC, and high LINC00662 levels correlated with poor survival of HCC patients. LINC00662 upregulated WNT3A expression and secretion via competitively binding miR-15a, miR-16, and miR-107. Through inducing WNT3A secretion, LINC00662 activated Wnt/?-catenin signaling in HCC cells in an autocrine manner and further promoted HCC cell proliferation, cell cycle, and tumor cell invasion, while repressing HCC cell apoptosis. |
| Pubmed ID | 31785055 |
| Year | 2019 |
| Title | Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/?-catenin signaling |
External Links
| Links for LINC00662 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |