Basic Information
| LncRNA/CircRNA Name | LINC00665 |
| Synonyms | NA |
| Region | GRCh38_19:36313067-36331718 |
| Ensemble | ENSG00000232677 |
| Refseq | NR_038278 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, PC-3, DU-145 and 22RV1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00665 high expression was related to a poor prognosis. LINC00665 knockdown markedly attenuated growth and metastasis of PC cells and impaired tumor propagation in vivo. Mechanistic investigation revealed that LINC00665 was the sponge for miR-1224-5p. |
| Pubmed ID | 32273723 |
| Year | 2020 |
| Title | LncRNA LINC00665 Promotes Prostate Cancer Progression via miR-1224-5p/SND1 Axis |
External Links
| Links for LINC00665 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |