Basic Information
| LncRNA/CircRNA Name | LINC00668 |
| Synonyms | NA |
| Region | GRCh38_18:6919496-6929966 |
| Ensemble | ENSG00000265933 |
| Refseq | NR_034100 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | glioblastoma tissues,cell lines (T98G, U87, U251 and A172) |
| Expression Pattern | up-regulated |
| Function Description | LINC00668 was significantly up-regulated in HCC tissues and cell lines. LINC00668 knockdown inhibited cell proliferative, migratory and invasion abilities and slowed down the epithelial-mesenchymal transition (EMT) process. Mechanistically, LINC00668 positively modulates the expression of YY1 by competitively binding to miR-532-5p. It was revealed that LINC00668 up-regulation accelerated cell proliferation and motility in HCC and suggested LINC00668 could be a potential therapeutic target for HCC. |
| Pubmed ID | 32249890 |
| Year | 2020 |
| Title | LncRNA LINC00668 Promotes Cell Proliferation, Migration, Invasion Ability and EMT Process in Hepatocellular Carcinoma by Targeting miR-532-5p/YY1 Axis |
External Links
| Links for LINC00668 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |