Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1 |
| Region | GRCh38_17:72403322-72592804 |
| Ensemble | NA |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RNAi |
| Sample | hepatocellular carcinoma tissues, cell lines (HCCLM3, MHCC97L,HepG2, Hep3B and Huh7,THLE-3, L-02) |
| Expression Pattern | up-regulated |
| Function Description | LINC00673 was upregulated in HCC cancerous tissue. LINC00673 overexpression is associated with poor prognosis and low survival rate. LINC00673 silencing inhibited the proliferation,invasion and epithelial-mesenchymal transition (EMT) of HCC cells in vitro. miR-205 targeted 3'-UTR of LINC00673.miR-205 could reverse the effect of LINC00673 on HCC cells.LINC00673 silencing reduced the tumor volume and weight. |
| Pubmed ID | 29312806 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00673 promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205 |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |