Basic Information
| LncRNA/CircRNA Name | LINC00704 |
| Synonyms | MANCR |
| Region | GRCh38_10:4650185-4678154 |
| Ensemble | ENSG00000231298 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, Western blot, in vitro knockdown etc. |
| Sample | cell lines (MCF-10A, MDA-MB-231), aggressive breast cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | MANCR (mitotically-associated long noncoding RNA; LINC00704), which is upregulated in breast cancer patient specimens and cells. Depletion of MANCR in triple-negative breast cancer cells significantly decreases cell proliferation and viability, with concomitant increases in DNA damage. MANCR expression is highest in mitotic cells by both RT-qPCR and RNA in situ hybridization. Consistent with a role in cell-cycle regulation, MANCR-depleted cells have a lower mitotic index and higher incidences of defective cytokinesis and cell death.MANCR, in genomic stability of aggressive breast cancer, and identify it as a potential therapeutic target |
| Pubmed ID | 29378907 |
| Year | 218 |
| Title | Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. |
External Links
| Links for LINC00704 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |