Basic Information
| LncRNA/CircRNA Name | LINC00707 |
| Synonyms | NA |
| Region | GRCh38_10:6779598-6842906 |
| Ensemble | ENSG00000238266 |
| Refseq | NR_038291 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP, etc. |
| Sample | GC tissues, GC cell lines (BGC-823, SGC-7901, MGC-803 and AGS) and the normal human gastric epithelium cell line (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00707 was excessively expressed in GC tissues and correlated with advanced stage, larger tumor size, lymph node metastasis and poorer prognosis in GC patients. In vitro and in vivo assays showed that LINC00707 promote GC cell proliferation and metastasis. Mechanistically, LINC00707 could abundantly interact with mRNA stabilizing protein HuR; LINC00707-HuR coalition ulteriorly combined with VAV3/F11R mRNAs and increased their stability. Taken together, our findings prove that LINC00707 may act as an oncogene in GC by regulating mRNA stability and serve as a potential target for GC diagnosis and prognosis. |
| Pubmed ID | 30502359 |
| Year | 2018 |
| Title | The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR |
External Links
| Links for LINC00707 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |