Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | NA |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | CRC tissues and the corresponding adjacent non-cancerous tissues,cell lines(TP53-WT, RKO, HCT116, Colo-678, LoVo, SW48, LS174T, CCD-112CoN) |
| Expression Pattern | up-regulated |
| Function Description | The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was increased in CRC tumor tissues, and patients with high LINC00858 expression had a shorter survival time. |
| Pubmed ID | 32323793 |
| Year | 2020 |
| Title | Long non-coding RNA LINC00858 promotes TP53-wild-type colorectal cancer progression by regulating the microRNA-25-3p/SMAD7 axis |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |