Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | NA |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Dual luciferase reporter assay, RIP, qRT-PCR, Western blot |
| Sample | CRC and adjacent normal tissues,CRC cell lines (T84, HCT 116, SW480 and HT-29) and NCM460 |
| Expression Pattern | up-regulated |
| Function Description | With a predicted poor prognosis, LINC00858 was upregulated in CRC patients. LINC00858 knockdown suppressed cell proliferation, invasion, and migration abilities, meanwhile induced cell apoptosis. Moreover, LINC00858 could target and inhibit the miR-4766-5p expression, thus promoting CRC progression. |
| Pubmed ID | 31902050 |
| Year | 2020 |
| Title | LINC00858 Promotes Colorectal Cancer by Sponging miR-4766-5p to Regulate PAK2 |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |